Work

A 68Ga-/Gd labeled PET/MR imaging probe for pH assessment

Year: 2026

Type: article

Abstract: A dual PET/MRI tumor and pH functional imaging system has been synthesized. This system can simultaneously quantify the pH by PET and localize this data by CEST-based MRI. Chemically Gd-DO3A + 68Ga-NOTA radioisotope chelate dual system was coupled to avidin-biotin carrier system. This method offers a double pH sensing option for image-based diagnostics and theragnostics.

Source: EJNMMI Research

DOI: 10.1186/s13550-025-01330-7

Authors: Noémi Kovács, Imre Hegedüs, Kálmán Nagy, Eliana Gianolio, Roberta Napolitano, Francesca Arena, Bengt Långström, Krisztián Szigeti, Miklós Tóth, Balázs Gulyás, Domokos Máthé, Christer Halldin, Silvio Aime

Institutions: Semmelweis University, University of Turin, Uppsala University, Karolinska Institutet, Nanyang Technological University

Language: English

Topic: Radiopharmaceutical Chemistry and Applications

Subfield: Radiology, Nuclear Medicine and Imaging

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,190

Funders: Magyarország Kormánya, Horizon 2020 Framework Programme, National Research, Development and Innovation Office

Awards: G2642974238, G4546253015

OpenAlex ID: W7123886924

FWCI: 4.593

Cites: 30

Cited by: 1

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