Real-world multicenter assessment of sustained clinical outcomes after digital deep brain stimulation
Year: 2026
Type: article
Abstract: Remote, internet-based deep brain stimulation programming for Parkinson's disease accelerates clinical benefits postoperatively by improving access to therapy adjustments compared to in-clinic optimization. After completion of the initial digital programming phase, we show that clinical outcomes, quality of life, and safety remain sustained over at least twelve months under routine care conditions. Embedding a randomized trial within a larger cohort study enables long-term, real-world evaluation, offering a scalable and pragmatic model for assessing complex digital interventions in routine clinical care. (NCT05269862 registered on 2022-03-08 and NCT04071847 registered on 2019-08-28).
Source: npj Digital Medicine
Authors: Alireza Gharabaghi, Sergiu Groppa, Elena Casas, Alfons Schnitzler, Laura Muñoz-Delgado, Vicky L. Marshall, Jessica Karl, Lin Zhang, Ramiro Alvarez, Mary S. Feldman, Michael J. Soileau, Lan Luo, Benjamin L. Walter, Chengyuan Wu, Hong Lei, Damian M. Herz, Devyani Nanduri, Claudia A. Salazar, Corneliu Luca, Daniel Weiss
Institutions: Universitätsklinikum Tübingen, Deutsches Zentrum für Psychische Gesundheit, University of Tübingen, Universitätsklinikum des Saarlandes, Hospital Universitario de La Princesa, Düsseldorf University Hospital, Heinrich Heine University Düsseldorf, Instituto de Salud Carlos III, Biomedical Research Networking Center on Neurodegenerative Diseases, Centro de Investigación Biomédica en Red, Instituto de Biomedicina de Sevilla, Hospital Universitario Virgen del Rocío, Universidad de Sevilla, Queen Elizabeth University Hospital, Northwestern University, Rush University, University of California, Davis, Hospital Universitari Germans Trias i Pujol, Dartmouth–Hitchcock Medical Center, Beth Israel Deaconess Medical Center, Harvard University, Indiana University School of Medicine, Thomas Jefferson University, University of Arizona, University of Miami, Hertie Institute for Clinical Brain Research
Language: English
Subfield: Neurology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $4,090
Funders: Biogen, Teva Pharmaceutical Industries, Alexion Pharmaceuticals, Boston Scientific Corporation, Jazz Pharmaceuticals, Parkinson's Foundation, Nevro, Amneal Pharmaceuticals, European Commission, Deutsche Forschungsgemeinschaft, Bundesministerium für Bildung und Forschung, Mitsubishi Tanabe Pharma Corporation, Ipsen, National Institutes of Health
Award: G4619505372
OpenAlex ID: W7123960945