Work

Recurrent Orbital Metastases in Follicular Variant Papillary Thyroid Carcinoma After Recombinant Human Thyrotropin

Year: 2025

Type: article

Abstract: Recombinant human thyrotropin (rhTSH) is generally well tolerated with minimal adverse effects. Symptomatic tumor expansion following rhTSH has been previously reported in the literature. Generally, these cases have involved known metastasis of aggressive variants. In this report we present a case of follicular variant papillary thyroid carcinoma (FVPTC) with recurrent treated orbital metastases and adverse response to rhTSH. Following a second dose of rhTSH, the patient reported right eye proptosis, and edema was noted on imaging. Iodine-131 scan demonstrated intense right orbital uptake with intracranial extension verified on head scans. Biopsy confirmed FVPTC and she underwent orbitotomy and enucleation. Our case illustrates the potential risk of symptomatic expansion even in cases of previously treated metastasis.

Source: JCEM Case Reports

DOI: 10.1210/jcemcr/luaf320

Authors: Eiman Ibrahim, Lilamani Kurukulasuriya, Tabitha Galloway, Mohamed Elbanan, Muhammad Moseeb Ali Hashim, Michael Gardner

Institution: University of Missouri

Language: English

Topic: Thyroid Cancer Diagnosis and Treatment

Subfield: Endocrinology, Diabetes and Metabolism

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $930