An expert opinion on heart failure in hypertensive heart disease
Year: 2026
Type: article
Abstract: There is strong evidence that hypertension is a major risk factor for heart failure (HF). Hypertension contributes to incident HF through direct and indirect effects. Indirect effects are consequences of ischaemic heart disease because hypertension facilitates atherosclerotic obstructive coronary artery disease. The direct effects are straightly related to hypertensive heart disease (HHD). Hypertensive heart disease poses a significant challenge with substantial medical and public health implications. Efforts should be made to recognize and manage HHD in a timely manner and optimize hypertension treatment. Reducing blood pressure (BP) and/or reassessing antihypertensive therapy using traditional or novel approaches can halt or delay progression to HF in patients with HHD and possibly prevent it. However, HHD's importance as a risk factor for overt HF is often overlooked in clinical practice. This document aims to summarize the current understanding of the burden of HHD and its risk for incident HF, discuss the mechanisms underlying HHD-related HF onset and progression, consider how diagnostic tools contribute to individualized phenotyping and HF risk stratification of HHD, address how therapeutic measures ameliorating or even preventing structural and functional alterations of HHD, along with BP control influence HHD-associated HF risk.
DOI: 10.1093/ejhf/xuag004
Authors: Javier Díez, Arantxa González, Annet Kirabo, Paolo Verdecchia, Tazeen H Jafar, Dagfinn Aune, Luke J Laffin, Thilo Burkard, Giuseppe M Rosano, Massimo Piepoli, Arthur Mark Richards, Begoña López, Susana Ravassa, Calvin W L Chin, Franz H Messerli, Thomas H Marwick, Miguel Camafort, Giovanni de Simone, Jian Zhang, Bertram Pitt, Marijana Tadic, Cesare Cuspidi, Faiez Zannad, Marco Metra, Michael Böhm, Javed Butler
Institutions: Centro de Investigación Médica Aplicada, Universidad de Navarra, Instituto de Salud Carlos III, Centro de Investigación en Red en Enfermedades Cardiovasculares, Navarre Institute of Health Research, Clinica Universidad de Navarra, Vanderbilt University Medical Center, Azienda Ospedaliera di Perugia, Duke-NUS Medical School, Norwegian Institute of Public Health, Cancer Registry of Norway, Imperial College London, Cleveland Clinic, University Hospital of Basel, San Raffaele University of Rome, University of Milan, IRCCS Policlinico San Donato, University of Otago, National Heart Centre Singapore, University of Bern, Jagiellonian University, Baker Heart and Diabetes Institute, Menzies Institute for Medical Research, Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition, Hospital Clínic de Barcelona, Universitat de Barcelona, NewYork–Presbyterian Hospital, University of Naples Federico II, Chinese Academy of Medical Sciences & Peking Union Medical College, Fu Wai Hospital, State Key Laboratory of Cardiovascular Disease, University of Michigan, Michigan Medicine, University Hospital Ulm, University of Milano-Bicocca, Inserm, Centre Hospitalier Régional et Universitaire de Nancy, French Clinical Research Infrastructure Network, Défaillance Cardiovasculaire Aiguë et Chronique, Université de Lorraine, Vita-Salute San Raffaele University, IRCCS Ospedale San Raffaele, Universitätsklinikum des Saarlandes, Saarland University, University of Mississippi, Baylor Scott & White Research Institute
Language: English
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: green
Award: G8048359887
OpenAlex ID: W7124145303