Novel assessment of postprandial metabolism reveals sex-specific metabolic flexibility and lipid remodeling following volumetric muscle loss
Year: 2026
Type: article
Abstract: We developed a novel, freely ambulatory preclinical tool to assess dynamic postprandial metabolic flexibility. Using this tool, we identified sex differences in whole body energy expenditure and substrate utilization. The use of a single intramuscular glycerol injection model is not sufficient as a comparative model for evaluating chronic ectopic lipid accumulation and metabolic disruptions. In the context of volumetric muscle loss injury, disruptions in metabolic flexibility occur alongside alterations in lipid handling and ectopic lipid accumulation.
Institutions: University of Minnesota, University of Georgia
Language: English
Subfield: Physiology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W7124156165