Work

Vascular endothelial function is preserved in women with a history of preeclampsia currently receiving antidepressant pharmacotherapy

Year: 2026

Type: article

Abstract: To our knowledge, this is the first study to demonstrate that chronic antidepressant use is associated with preserved endothelial function in women with a history of preeclampsia (hxPE). Compared with healthy controls, untreated women with hxPE had reduced macrovascular (brachial artery) and microvascular (cutaneous) endothelial function, whereas those treated with antidepressants exhibited preserved endothelial function. These findings suggest that antidepressants may modulate persistent endothelial dysfunction in these women following preeclampsia.

Source: American Journal of Physiology-Heart and Circulatory Physiology

DOI: 10.1152/ajpheart.00890.2025

Authors: Ruda Lee, Jody L. Greaney, Mark K. Santillan, Gary L. Pierce, Anna E. Stanhewicz

Institutions: University of Iowa, University of Delaware

Language: English

Topic: Pregnancy and preeclampsia studies

Subfield: Obstetrics and Gynecology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: American Heart Association, National Center for Advancing Translational Sciences