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Outside Front Cover: Surface Avidity of Anionic Polypeptide Coatings on Layer‐by‐Layer Nanoparticles Target Cancer‐Associated Amino Acid Transporters (Angew. Chem. Int. Ed. 8/2026)

Year: 2026

Type: article

Abstract: In their Research Article (e19203), Darrell J. Irvine, Paula T. Hammond, and co-workers uncover that the dense presentation of anionic amino-acid motifs on layer-by-layer nanoparticles (green) enables selective recognition of amino-acid transporters on cancer cells (pink; blue nucleus; white indicates NP–receptor colocalization). These findings define a transporter-targeting mode of action for a nanoparticle delivery platform with demonstrated preclinical activity.

Source: Angewandte Chemie International Edition

DOI: 10.1002/anie.2026-m1001093800

Authors: Ivan S. Pires, Margaret M. Billingsley, Ezra Gordon, Andrew J. Pickering, Eva Cai, Gonzalo J. Esparza, Mae L. Pryor, Alexander D. Stoneman, Aidan Kindopp, Darrell J. Irvine, Paula T. Hammond

Institutions: Koch Institute for Integrative Cancer Research At MIT, Massachusetts Institute of Technology, Howard Hughes Medical Institute, Harvard University, Ragon Institute of MGH, MIT and Harvard

Language: English

Topic: Nanoparticle-Based Drug Delivery

Subfield: Biomaterials

Field: Materials Science

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W7124163034

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