Work

2′-hydroxyl modification improves enzymatic and thermal stability of mRNA

Year: 2026

Type: article

Abstract: In a recent issue of Molecular Therapy Nucleic Acids, Yamada et al. reported that chemical modification of the 2′-hydroxyl groups of mRNA ribose improves enzymatic and thermal stability with reduced but still detectable translational activity.1 The 2′-hydroxyl groups are key contributors to mRNA degradation, both through ribonuclease (RNase) attack in physiological environments and hydrolysis during storage. Therefore, chemical modification of the 2′-hydroxyl groups is expected to mitigate both degradation mechanisms.

Source: Molecular Therapy — Nucleic Acids

DOI: 10.1016/j.omtn.2025.102821

Author: Satoshi Uchida

Institutions: Innovation Center of NanoMedicine, Institute of Science Tokyo, The University of Tokyo

Language: English

Topic: RNA Interference and Gene Delivery

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: gold

Estimated APC paid: $3,900

OpenAlex ID: W7124165035