Work

Spatiotemporal dynamics of mammalian wound healing

Year: 2026

Type: article

Abstract: Mammalian wound healing is orchestrated by tightly regulated cellular and molecular programs across the hemostasis, inflammation, proliferation, and remodeling phases. Here, we propose the concept of spatiotemporal clocks as a unifying framework for understanding how transitions between phases are coordinated. We dissect the roles of distinct spatial domains: epidermis, dermis, fascia, wound edges, and wound center, and highlight the oscillatory molecular signals that govern their dynamic interactions. Special attention is given to wound-induced hair neogenesis (WIHN) as a model of regenerative potential. By integrating spatial and temporal dimensions, this framework unifies the multidimensional aspects of wound healing, laying a robust foundation for the development of innovative therapeutic strategies.

Source: Cell Discovery

DOI: 10.1038/s41421-025-00865-2

Authors: Julià Agramunt, Yuanbo Kang, Yuval Rinkevich

Institutions: Chinese Academy of Medical Sciences & Peking Union Medical College, Peking Union Medical College Hospital, Capital Medical University

Language: English

Topic: Wound Healing and Treatments

Subfield: Rehabilitation

Field: Medicine

Domain: Health Sciences

Open Access status: gold

Estimated APC paid: $3,590

Funder: Cambridge Institute for Medical Research, University of Cambridge