Targeting activated kidney fibroblasts via ferroptosis: a potential antifibrotic strategy
Year: 2026
Type: article
Abstract: This study reveals ferroptosis, a pharmacologically inducible form of cell death, as a novel mechanism to eliminate activated fibroblasts, the main drivers of kidney fibrosis. Due to their high ferroptosis sensitivity, these cells are selectively depleted by RSL3 in vitro, in kidney tissue slice cultures, and in fibrotic kidneys in vivo. These findings highlight ferroptosis induction as a promising antifibrotic strategy in kidney disease.
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Funder: Deutsche Forschungsgemeinschaft
Awards: G2591914479, G787599765, G8515066740
OpenAlex ID: W7124183979