CD4+ T cells mediate CAR-T cell-associated immune-related adverse events after BCMA CAR-T cell therapy
Year: 2026
Type: article
Study design: Observational Study
Source: Nature Medicine
Authors: Matthew Ho, Luca Paruzzo, Julia Han Noll, Federico Stella, Pooja Devi, Sonia Ndeupen, Yael A. Day, Gregory M. Chen, Ivan J. Cohen, Angel Ramirez-Fernandez, Adam Waxman, Shivani Kapur, Fang Chen, Rong Xu, Andrew Huff, Danuta Jarocha, Vrutti Patel, Audrey C. Bochi-Layec, Ranjani Ramasubramanian, Shan Liu, Riemke Bouvier, Vitor B. de Souza, Heta Patel, Ziyu Li, Alberto Carturan, Peter Michener, Caitlin R. Hopkins, Owen Koucky, Janna Minehart, Alex Dimitri, Neel R. Nabar, Zainul S. Hasanali, Bryan T. Ciccarelli, Putzer Hung, Erik Williams, Robert Bartoszek, Maya Lavorando, Suyash Mohan, Vanessa E. Gonzalez, Patrizia Porazzi, Vijay G. Bhoj, Sokratis A. Apostolidis, Dan T. Vogl, David L. Porter, John Scholler, Caroline Diorio, Aoife M. Roche, John K. Everett, Frederic D. Bushman, Katherine L. Nathanson, Edward A. Stadtmauer, Sandra P. Susanibar-Adaniya, Alfred L. Garfall, Marco Ruella, Adam D. Cohen, Joseph A. Fraietta
Language: English
Topic: CAR-T cell therapy research
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: green
Funders: National Science Foundation, Alliance for Cancer Gene Therapy, Alex's Lemonade Stand Foundation for Childhood Cancer, Rheumatology Research Foundation, University of Pennsylvania, Computational Diagnostics, Parker Institute for Cancer Immunotherapy, National Institutes of Health, National Human Genome Research Institute, National Cancer Institute
Awards: Mechanisms of TET2-dependent control of CAR T cell fate determination and antitumor function, G1568174014, G1980627781, Linking insertional mutagenesis and cell function to improve CAR T cell therapy, G3326864172, G5520316217, G9000188555, Single-cell dissection of CD4 T cell changes in patients with immune-related adverse events following PD-1 inhibition, Calming the Cytokine Storm: Unraveling the Biology of CRS and ICANS, Postdoctoral Training Program in Genomic Medicine, Enhancing Chimeric Antigen Receptor T Cell Therapies for HematologicMalignancies: Beyond CART 19
OpenAlex ID: W7124246452