Thalidomide Modulates Oxidative Stress and Tubular Pathology in Renal Ischemia-Reperfusion in a Timing-Dependent Manner
Year: 2026
Type: article
Abstract: Background: Renal ischemia–reperfusion (IR) drives acute kidney injury through oxidative stress and inflammation. Thalidomide (TD), an immunomodulatory agent, may attenuate IR-related biochemical and structural damage. Methods: Thirty-two female Wistar albino rats were randomized to four groups (n=8): Sham, IR, TD+IR (20 mg/kg i.p. 30 min before ischemia), and IR+TD (20 mg/kg i.p. immediately after 60-min ischemia). All animals underwent right nephrectomy, left renal ischemia (60 min), and 24-h reperfusion. Outcomes included serum blood urea nitrogen (BUN)/creatinine (CR)/albumin; renal malondialdehyde (MDA), glutathione (GSH), superoxide dismutase (SOD), catalase (CAT); and histopathology (tubular dilatation, epithelial shedding, intertubular congestion). Results: IR increased BUN/CR versus Sham, while albumin was unchanged. TD+IR modestly lowered BUN/CR compared with IR, whereas IR+TD did not improve these indices at 24 h. MDA rose with IR and was reduced by TD+IR (vs IR), but not by IR+TD; CAT fell with IR and was highest in IR+TD, while GSH and SOD showed no significant group differences. Histologically, IR produced tubular epithelial shedding, dilatation, and intertubular congestion. TD+IR improved all parameters except epithelial shedding (vs IR), and IR+TD improved all except tubular dilatation; medullary congestion decreased in both TD groups, more prominently with IR+TD. Conclusion: TD confers schedule-dependent renoprotection in renal IR. Pre-ischemic dosing more consistently preserves function and limits lipid peroxidation, whereas post-ischemic dosing better enhances CAT activity and alleviates medullary congestion. These data support TD as a context-dependent adjunct for peri-ischemic kidney protection.
Source: Recent trends in pharmacology.
Institution: Inonu University
Language: English
Topic: Acute Kidney Injury Research
Subfield: Nephrology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W7124246796