Fusion gene discovery in single cells from high throughput long read single cell transcriptomes
Year: 2026
Type: preprint
Abstract: High throughput long-read single cell RNA sequencing allows for fusion gene discovery in thousands of cells in parallel, which is however constrained by the lack of robust computational tools. Here, we develop LongFUSE that employs the XOR logic operation and stringent filtering criteria for the accurate detection of cell-specific fusion genes and their splicing isoforms. LongFUSE outperforms existing tools in both simulation and real data, demonstrating high accuracy and robustness.
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
Awards: G3930547285, G460745846
OpenAlex ID: W7124249335