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Comparative Efficacy and Safety of Intramuscular Midazolam Versus Intravenous Lorazepam in Prehospital Management of Status Epilepticus: Evidence From Rampart Trial

Year: 2026

Type: article

Abstract: Background: Status Epilepticus (SE) is a life-threatening neurological emergency that requires immediate treatment. Intravenous (IV) lorazepam is a standard first-line therapy, but IV access is often delayed in Prehospital settings. Intramuscular (IM) Midazolam offers a potential alternative due to its ease of administration. Objective: To evaluate and compare the effectiveness of IM midazolam and IV lorazepam in terminating seizures in patients with status epilepticus in a Prehospital setting.

Source: World Journal of Pharmaceutical Research

DOI: 10.5281/zenodo.18255588

Author: P. Priyadharshini*1, S. Lakshmi1, V. Anushree1, M. Praveenkumar2, C. Jothimanivannan3

Language: English

Topic: Epilepsy research and treatment

Subfield: Psychiatry and Mental health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

OpenAlex ID: W7124255791

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