New mitochondrial KV1.3 conjugates are potent and specific inducers of apoptosis in cancer models

Year: 2026

Type: article

Abstract: 1.3 inhibitors with enhanced solubility compared to psoralen-based analogues. The unique mechanism of action, characterized by rapid depolarization and moderate ROS dependence, underscores their potential as selective anticancer agents. These findings warrant further investigation into in vivo efficacy and potential synergy with existing therapies.

Source: Biomedicine & Pharmacotherapy

DOI: 10.1016/j.biopha.2026.118996

Institutions: University of Ljubljana, Max Planck Society, Max Planck Institute for Multidisciplinary Sciences, National Institute of Biology, University of California, Davis, University of Padua, Institute of Oncology Ljubljana, University of Primorska, Jožef Stefan Institute

Language: English

Topic: Cell death mechanisms and regulation

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,610

Funders: Center for Advancing Research Impact in Society, European Commission, Max-Planck-Gesellschaft, Javna Agencija za Raziskovalno Dejavnost RS, Associazione Italiana per la Ricerca sul Cancro, Horizon 2020 Framework Programme, H2020 Marie Skłodowska-Curie Actions

Awards: G1554159396, G3328234244, G579052512, G7388391436, G8535864117, G8653440348

OpenAlex ID: W7124258508