Work

Reviewer #2 (Public review): map3k1 is required for spatial restriction of progenitor differentiation in planarians

Year: 2026

Type: peer-review

Abstract: eLife AssessmentThis important study examines the role of map3k1, a MAP3K family member that has both kinase and ubiquitin ligase domains, in the differentiation of progenitors in the flatworm Planaria.The convincing analyses demonstrate that map3k1 acts within progenitors to restrict their premature differentiation and to prevent formation of teratomas.This work would be of interest to researchers in the fields of regeneration, developmental biology, and aging.

Source: eLife

DOI: 10.7554/elife.106439.2.sa1

Language: English

Topic: Planarian Biology and Electrostimulation

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: gold

Estimated APC paid: $2,500

Funders: Howard Hughes Medical Institute, Broad Institute, National Institutes of Health, National Institute of General Medical Sciences

Award: Stem cell and regeneration regulatory mechanisms in planarians

OpenAlex ID: W7124263276

Cites: 1

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Related to: 10