Work

The unique cognitive phenotype of ASD + ADHD co-occurrence: evidence for planning and attention deficits as a differentiating approach

Year: 2026

Type: article

Abstract: Purpose: This study aimed to assess cognitive processing in children with autism spectrum disorder (ASD) without co-occurring attention-deficit/hyperactivity disorder (ADHD) (ASD-alone), children with ADHD without co-occurring ASD (ADHD-alone), and children with ASD with co-occurring ADHD (ASD + ADHD). Methods: = 58). The Das-Naglieri Cognitive Assessment System (D-N CAS) was applied to evaluate planning, attention, simultaneous, and successive cognitive processes. Results: Children with ASD-alone scored less on planning processing. Children with ADHD-alone scored lower on planning and attention processing. Children with ASD + ADHD scored lower on all four processes. Planning and attention exhibited satisfactory stratification precision in identifying ASD + ADHD among children with ASD, with area under the curve (AUC) values of 0.7426 and 0.8061, respectively. Successive processing had medium diagnostic value in diagnosing ASD + ADHD among children with ADHD, with an AUC of 0.618. Inattention symptoms were associated with planning and attention processing. Social affects and inattention symptoms were associated with the total D-N CAS score. Conclusion: Children with ASD-alone, ADHD-alone, and ASD + ADHD exhibited distinct cognitive profiles. The D-N CAS, particularly its planning and attention scales, provided an approach for differential diagnosis in clinical settings.

Source: Frontiers in Pediatrics

DOI: 10.3389/fped.2025.1703264

Authors: Tiantian Wang, Miaoshui Bai, Zunwei Zhang, Feiyong Jia

Institutions: Jilin University, First Hospital of Jilin University

Language: English

Topic: Autism Spectrum Disorder Research

Subfield: Cognitive Neuroscience

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,801