The value of Ultrasound Fat Fraction as compared to Controlled Attenuation Parameter for the severity of liver steatosis assessment - preliminary results
Year: 2026
Type: article
Study design: Observational Study
Abstract: AIM: Liver steatosis is a growing global health concern with significant medical and economic implications. This study aimed to evaluate USFF (ultrasound fat fraction) for steatosis assessment as compared to controlled attenuation parameter (CAP). MATERIALS AND METHODS: Liver steatosis was assessed in the same session by QUS (Samsung Medison RS85) and CAP (FibroScan Compact M530) in a cohort of 169 patients. For QUS, TAI and TSI measurements were acquired, then Fat Fraction (%) was calculated and displayed. The CAP cut-off values for S1, S2 and S3 were 248, 268 and 280 dB/m, respectively. ROC analysis was performed to identify the best cut-off values for USFF for each steatosis stage. RESULTS: Of the 169 patients, 52.6% had at least moderate steatosis by CAP. Moderate correlations were observed for TSI vs. CAP (r=0.66), TAI vs. CAP (r=0.83), and TSI vs. TAI (r=0.68), with good diagnostic performance (TSI AUROC=0.82, TAI AUROC=0.81). A strong correlation between USFF and CAP was also found (r=0.81, p<0.001). The best USFF cut-off value to identify at least mild steatosis in all patients was >5% with very good performance (AUROC=0.90) for moderate steatosis the cut-off value was >7.5% (AUROC=0.92) and for severe steatosis, >10% (AUROC=0.91). CONCLUSION: USFF seems to be a promising tool for diagnosing liver steatosis, with a very good performance.
Source: Medical Ultrasonography
DOI: 10.11152/mu-4575
Language: English
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W7124279919