Year: 2026
Type: article
Abstract: Carbohydrate-responsive element binding protein (ChREBP) and Max-like protein X (MLX) are key Mondo Family Proteins (MFPs) acting as transcription factors. They are known to couple intracellular sugar levels with carbohydrate and lipid metabolism by regulating glucose-responsive gene expression. MondoA regulates lipid metabolism and insulin signaling in addition to controlling glucose uptake, whereas ChREBP primarily regulates de novo lipogenesis and glycolysis. Differential gene expression data suggest that the expression of MondoA and ChREBP is cell type-specific, which is an important consideration when designing therapeutic strategies to control MFP-regulated transcriptional programs for different tissue-specific systems. In this review, we summarize recent advances made in the research field studying diabetes and its multi-organ complications, including those affecting the kidney, liver, heart, and retina. We also discuss recent advances in MFP-targeted therapies.
Source: Frontiers in Endocrinology
Institutions: Wake Forest University, University of Alabama at Birmingham
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $3,801
Funder: National Eye Institute
Award: G296357158
OpenAlex ID: W7124282104