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Comparison study of microfluidic sperm selection chips with density gradient centrifugation and upstream methods in sperm selection

Year: 2026

Type: article

Abstract: This study compared microfluidic sperm selection chips with density gradient centrifugation and swim-up methods using 60 semen samples. All techniques improved sperm motility and reduced DNA fragmentation, abnormal morphology, and leukocyte levels. The microfluidic chip yielded sperm with the best motility, morphology, and DNA integrity, though with a lower recovery rate and concentration than traditional methods. Progressive motility recovery rates were similar across groups. Despite lower sperm yield, microfluidic chips offer a promising option for selecting high-quality sperm in fertility treatments.

Source: African Journal of Reproductive Health

DOI: 10.29063/ajrh2026/v30i1.6

Authors: Xiuying Xu, Bo Huang, Chihua He, Lipan Ouyang

Institutions: Yangtze University, Tongji Hospital, Huazhong University of Science and Technology

Language: English

Topic: Sperm and Testicular Function

Subfield: Reproductive Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W7124282657

FWCI: 4.784

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Cited by: 1

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