Data for: Repeat-element RNAs integrate a neuronal growth circuit
Year: 2026
Type: dataset
Abstract: Neuronal growth and regeneration are regulated by local translation of mRNAs in axons. We examined RNA polyadenylation changes upon sensory neuron injury and found upregulation of a subset of polyadenylated B2-SINE repeat elements, hereby termed GI-SINEs (growth-inducing B2-SINEs). GI-SINEs are induced from ATF3 and other AP-1 promoter-associated extragenic loci in injured sensory neurons but are not upregulated in lesioned retinal ganglion neurons. Exogenous GI-SINE expression elicited axonal growth in injured sensory, retinal, and corticospinal tract neurons. GI-SINEs interact with ribosomal proteins and nucleolin, an axon-growth-regulating RNA-binding protein, to regulate translation in neuronal cytoplasm. Finally, antisense oligos against GI-SINEs perturb sensory neuron outgrowth and nucleolin-ribosome interactions. Thus, a specific subfamily of transposable elements is integral to a physiological circuit linking AP-1 transcription with localized RNA translation.
Authors: Zahavi, Eitan Erez, Koppel, Indrek, Kawaguchi, Riki, Oses, Juan A., Briner, Adam, Monavarfeshani, Aboozar, Costa, Irene Dalla, van Niekerk, Erna, Lee, Jinyoung, Matoo, Samaneh, Hegarty, Shane, Donahue, Ryan J., Sahoo, Pabitra K., Ben-Dor, Shifra, Feldmesser, Ester, Ryvkin, Julia, Leshkowitz, Dena, Ben Tov Perry, Rotem, Cheng, Yuyan, Farber, Eli, Abraham, Ofri, Okladnikov, Nataliya, Alber, Stefanie, Albus, Christin Anne, Rishal, Ida, Ulitsky, Igor, Tuszynski, Mark, Twiss, Jeffery L., He, Zhigang, Burlingame, Alma L.
Institutions: Weizmann Institute of Science, Tallinn University, University of California, Los Angeles, University of California, San Francisco, Harvard University, University of South Carolina, University of California San Diego, Rutgers, The State University of New Jersey, University of Pennsylvania, Newcastle University
Subfield: Cellular and Molecular Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W7124288998
Cites:
Cited by:
Related to: