Cardiovascular risk profile evolution over 15 years: comparison between CV-PREVITAL Trial and Moli-sani Study participants
Year: 2026
Type: article
Study design: Observational Study
Abstract: Fifteen years elapsed between two surveys of cardiovascular (CV) risk factors in the same Italian region. Modifiable CV risk profiles were compared among 2,199 individuals enrolled in the CV-PREVITAL trial (2022-2024) at IRCCS Neuromed with those of 16,656 participants from the Moli-sani Study (2005-2010), matched for age and absence of prior CV disease. The Moli-sani Risk Score is a validated algorithm incorporating nine common modifiable risk factors measured overall risk. Most individual risk factors were more favorable in CV-PREVITAL compared with Moli-sani participants, besides hypertension in men and glucose levels in women. Relative fat mass was similar in both cohorts. Men in CV-PREVITAL had a mean Moli-sani Risk Score 4.8 points lower than Moli-sani men; women showed a 4.5-point reduction. These findings suggest a meaningful decline in modifiable CV risk over a 15-year interval, potentially reflecting enhanced prevention awareness, improved therapeutic efficacy, and cumulative effects of long-term public health communication.
Language: English
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W7124291000