Work

Evaluation of the Cleveland Clinic Score for predicting acute kidney injury across different elective cardiac surgeries—a retrospective study

Year: 2026

Type: article

Abstract: Background Acute kidney injury (AKI) after cardiac surgery is a serious postoperative complication associated with an increased risk of mortality. The Cleveland Clinic Score (CCS) is one of the tools that allows preoperative assessment of the likelihood of developing AKI. However, the tool has not been validated in different types of cardiac surgery procedures. Our aim was to evaluate the CCS before different types of cardiac surgery and to assess the usefulness of this tool as a predictor of AKI. Methods In this retrospective study we included patients who underwent elective cardiac surgery in 2023. Our endpoint was AKI, as defined by the Kidney Diseases Improving Global Outcomes (KDIGO) criteria. The predictive value for AKI after cardiac surgery (CCS) was evaluated using receiver operating characteristic (ROC) curves and area under the curve (AUC) values. Results A total of 610 patients underwent elective cardiac surgery. Patients with and without AKI were divided into CCS stages: stage I (57.8 vs 72.3%), stage II (36.1 vs 26.1%), stage III (5.4 vs 1.6%), stage IV (0.6 vs 0%). The AUC for all operations was 0.630 (95% CI [0.580–0.679], p < 0.001), stage I 0.428 (95% CI [0.376–0.480]; p = 0.006), stage II 0.550 (95% CI [0.498–0.602]; p = 0.057) and for stage III 0.519 (95% CI [0.467–0.572]; p = 0.464). The AUC values were significant only for coronary artery bypass grafting (CABG) 0.650 (95% CI [0.552–0.748]) and aortic valve replacement/plasty (AVR/AVP) 0.629 (95% CI [0.550–0.709]). Conclusions The overall CCS value showed a moderate predictive ability for AKI (AUC 0.630) and particularly useful for predicting renal replacement therapy (RRT), but for individual groups the scale should be modified by adding several new factors.

Source: PeerJ

DOI: 10.7717/peerj.20533

Authors: Mateusz Kozioł, Vladyslav Kyslyi, Dorota Sobczyk, Jacek Piatek, Janusz Konstanty-Kalandyk

Institutions: Jagiellonian University, John Paul II Hospital

Language: English

Topic: Acute Kidney Injury Research

Subfield: Nephrology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,395