Work

The expanding role of Nogo-B in hypertension: linking kidney physiology, endothelial function and inflammation

Year: 2026

Type: article

Abstract: Although Nogo-B has been studied in neural development and vascular biology, its integrative role across renal, vascular and inflammatory pathways in hypertension has not yet been systematically reviewed. Here, we synthesize emerging evidence positioning Nogo-B as a central modulator of blood pressure control. Its expression in the aldosterone-sensitive distal nephron and vascular endothelium suggests a central role in electrolyte and fluid balance, as well as vascular physiology. By bridging insights from the renal, vascular and immune systems, we position Nogo-B as an emerging contributor to blood pressure regulation and highlight its potential both as a biomarker for vascular dysfunction and as a therapeutic target in salt-sensitive and treatment-resistant hypertension.

Source: Journal of Hypertension

DOI: 10.1097/hjh.0000000000004239

Authors: Filipy Borghi, Yannan Jiang, Luigi Gnudi

Institutions: King's College London, British Heart Foundation, Guy's Hospital, St Thomas' Hospital, Guy's and St Thomas' NHS Foundation Trust

Language: English

Topic: Renin-Angiotensin System Studies

Subfield: Cardiology and Cardiovascular Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: British Heart Foundation, Diabetes UK