Work

Construction of remote dual stereocenters by electrochemical cobalt-catalyzed enantioselective desymmetrization

Year: 2026

Type: article

Abstract: The enantio- and diastereoselective construction of two stereogenic centers represents a highly attractive objective in synthetic chemistry. Extensive asymmetric catalytic methods have been developed for the formation of vicinal stereocenters. In contrast, the simultaneous construction of two constitutionally distinct stereogenic centers at remote positions in a single asymmetric catalytic step remains very scarce, owing to the lack of reliable models for distant stereochemical induction for both chiral entities. Herein, we report on an electrochemical cobalt-catalyzed asymmetric hydroacylation of enynes by a desymmetrization strategy that enables the enantio- and diastereo-selective construction of remote dual stereocenters. This unified catalytic platform exhibits broad substrate generality and affords four distinct classes of chiral products, each incorporating two chiral elements: 1,6-central/C-C axial chirality, 1,6-central/C-O axial chirality, 1,5-central/[2.2]paracyclophane planar chirality, and 1,5-central/ferrocene planar chirality.

Source: Nature Communications

DOI: 10.1038/s41467-026-68437-w

Authors: Yanjun Li, Siyu Liu, Binbin Yuan, Nico Graw, Lutz Ackermann

Institutions: University of Göttingen, Rheinland-Pfälzische Technische Universität Kaiserslautern-Landau

Language: English

Topic: Asymmetric Synthesis and Catalysis

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: gold

Estimated APC paid: $6,990

Funders: European Commission, Deutsche Forschungsgemeinschaft, China Scholarship Council, Leibniz-Gemeinschaft