Work

Concurrent associations between visit-to-visit changes in actigraphy-based physical activity and cognitive aging in older adults

Year: 2026

Type: article

Abstract: Physical activity (PA) is associated with lower dementia risk, yet few studies examine objectively measured PA with concurrently measured brain and cognitive aging outcomes longitudinally, leaving a gap in knowledge regarding temporality of these brain-behavior associations. We examined how longitudinal within-person changes in average daily step count track with changes in memory, executive function, hippocampal volumes, white matter hyperintensities (WMH), and depressive symptoms over time. 107 older adults completed neuropsychological testing and brain magnetic resonance imaging, followed by 30-day Fitbit monitoring at two or more annual study visits at the UCSF Memory and Aging Center. Linear mixed-effects models examined each brain health outcome as a function of visit-to-visit PA, time (years since baseline), baseline age, sex, education, and total intracranial volume (neuroimaging models only). Within-person increases in daily step count were most strongly associated with within-person increases in executive functioning (Std. β = 0.128, 95%CI [0.056, 0.200], p ≤ 0.001) and decreases in depressive symptoms (Std. β = -0.201, 95%CI [-0.284, -0.119], p ≤ 0.001). Longitudinal PA associations with memory, hippocampal volumes, and WMH did not reach statistical significance. Findings suggest that within-person changes in PA may reduce real-time risk of cognitive decline; additionally, real-world monitoring of movement via actigraphy may be sensitive to early and subtle aspects of neurobehavioral declines with aging. • We tracked changes in older adults’ physical activity and brain health over time • Increases in daily step count associated with increases in executive functioning • Increases in daily step count associated with reduced depressive symptoms • Acute changes in physical activity may benefit brain health even in older ages

Source: Neurobiology of Aging

DOI: 10.1016/j.neurobiolaging.2026.01.004