Work

Platelet recovery delay and survival in patients with myelofibrosis undergoing allogeneic hemopoietic stem cell transplantation

Year: 2026

Type: article

Abstract: We studied platelet recovery in 93 patients with myelofibrosis, following an allogeneic hemopoietic stem cell transplant (HSCT). The primary end point of the study was achieving a platelet count of 50x109/L within day +100 post transplant, which occurred in 62 patients (67%), predicted 5-year non-relapse mortality (NRM) (5% vs. 55%, P=0.0009) and 5-year actuarial survival (85% vs. 38%, P<0.00001); relapse was unaffected. The cumulative incidence of strong platelet recovery was predicted by a matched sibling donor (MSD) compared to alternative donors (90% vs. 60%, P=0.001), by the dose of CD34+ cells (cut off 8.68x106/kg; 83% vs. 61%, P=0.01), recipient age (cut off 63 years; 72% vs. 48%, P=0.01), and splenectomy (86% vs. 63%, P=0.04). In multivariate Cox analysis, significant predictors of platelet recovery were a MSD (P=0.003), a high CD34 cell dose (P=0.02), splenectomy (P=0.003), and younger patient age (P=0.02). Patients with slow platelet recovery have significantly lower platelet counts long term, combined with chronic graft-versus-host disease. In conclusion, strong post-HSCT platelet recovery in MF patients is mainly predicted by donor type, together with CD34 cell dose and patient age, and is strongly associated with NRM and survival.

Source: Haematologica

DOI: 10.3324/haematol.2025.288371