Work

Head mild hypothermia treatment after successful mechanical thrombectomy in anterior circulation large-vessel occlusion acute cerebral infarction

Year: 2026

Type: article

Study designs: Randomized Controlled Trial, Clinical Trial

Abstract: OBJECTIVE: To explore the effectiveness and safety of head mild hypothermia treatment after mechanical thrombectomy in anterior circulation large-vessel occlusion acute cerebral infarction. METHODS: Prospective inclusion of patients with anterior circulation large-vessel occlusion acute cerebral infarction treated with successful mechanical thrombectomy admitted to our hospital from December 2022-December 2024. The patients were randomly divided into a head mild hypothermia treatment group and a control group at a ratio of 1:2. Patients in the head mild hypothermia treatment group received head mild hypothermia treatment for 24 h after successful mechanical thrombectomy, while the control group did not receive head mild hypothermia treatment. Indicators such futile recanalization rate, symptomatic hemorrhage rate, cerebral herniation rate, stroke-related pneumonia rate, and mortality rate of patients were analyzed. RESULTS: A total of 150 patients were included, with 50 in the head mild hypothermia treatment group and 100 in the control group. The futile recanalization rate in the head mild hypothermia treatment group was significantly lower than that of the control group (32.00% vs 51.00%, P = 0.027), and the 3-month postoperative mortality rate was significantly lower than that of the control group (4.00% vs 15.00%, P = 0.045). CONCLUSION: After successful mechanical thrombectomy for anterior circulation large-vessel occlusion acute cerebral infarction, head mild hypothermia treatment can reduce the futile recanalization rate and 3-month postoperative mortality rate of patients, but cannot reduce the incidence of symptomatic cerebral hemorrhage and cerebral herniation in patients.

Source: European journal of medical research

DOI: 10.1186/s40001-026-03896-x