Work

Intense FAPI Uptake of Pancreatic Tissue Can Mask the Tumor Activity of Pancreatic Cancer: The Importance of Dual-Tracer PET Imaging

Year: 2026

Type: article

Abstract: Fibroblast activation protein (FAPI), a type II transmembrane glycoprotein is a promising target to image epithelial originated cancers.Pancreatic cancer is characterized with [ 68 Ga]Ga-FAPI-04 and 18 F-fluorodeoxyglucose ( 18 F-FDG) uptake in varying degree.However physiologic uptake and uptake associated with acute/chronic pancreatitis makes interpretation challenging.We would like to present a case of pancreatic cancer whose tumor could not delineated from rest pancreatic tissue in [ 68 Ga]Ga-FAPI-04 positron emission tomography/computed tomography (PET/CT) images due to intense FAPI uptake in whole pancreas but more remarkable in 18 F-FDG PET/CT images.

Source: Molecular Imaging and Radionuclide Therapy

DOI: 10.4274/mirt.galenos.2025.91069

Authors: Elife Akgün, Ahmet Ertuğrul Öztürk, Göksel Alçın, Mert Mahsuni Sevinç, Esra Arslan

Institution: Sağlık Bilimleri Üniversitesi

Language: English

Topic: Peptidase Inhibition and Analysis

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W7124318022