Work

Mechanical regulation of metabolism, epigenetics, and their interplay

Year: 2026

Type: article

Abstract: Mechanical cues from the cellular microenvironment critically influence cell behavior, fate, and function through coordinated regulation of metabolism and gene expression. This review discusses how mechanical signals are sensed and transduced into biochemical responses that reshape metabolic pathways and the epigenetic landscape. We highlight emerging evidence linking mechanotransduction, metabolic reprogramming, and chromatin modifications, and propose directions for future research to unravel how mechanical forces orchestrate this dynamic and reciprocal interplay.

Source: npj Biomedical Innovations.

DOI: 10.1038/s44385-025-00059-1

Authors: Hoonsik Nam, Gyusang Yu, Seor I Ahn, Sungmin Nam

Institution: University of Michigan

Language: English

Topic: Cellular Mechanics and Interactions

Subfield: Cell Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,690