Work

Myofibroma of the nasal vestibule: a case report and review of the literature

Year: 2025

Type: article

Abstract: Myofibroma is a rare benign myofibroblastic tumour of spindle cell differentiation. Most commonly, myofibromas are observed in the context of a myofibromatosis disorder in children. Rarely, myofibroma can present as a solitary lesion in adults. We report a rare case of solitary myofibroma of the nasal vestibule which presented as a nonhealing ulcer on the anterior nasal septum. This is described in the context of a comprehensive literature review. Punch biopsies were obtained which revealed histological appearances in keeping with myofibroma. Following discussion at the regional head and neck and sarcoma multidisciplinary meetings, surgical excision was performed with staged reconstruction. To our knowledge, this is the first reported case of myofibroma arising from the anterior nasal septum and columella. This case highlights the importance of considering myofibroma as a differential diagnosis for nonhealing ulceration in this anatomical location.

Source: Journal of Surgical Case Reports

DOI: 10.1093/jscr/rjaf969

Authors: James E Holland, Emily Lowe, Karwan Moutasim, Badri Srinivasan, Rami J Salib, Huw A S Jones

Institutions: University Hospital Southampton NHS Foundation Trust, University of Southampton

Language: English

Topic: Soft tissue tumor case studies

Subfield: Rheumatology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,000