Work

How do infant brains fold? Sulcal deepening is linked to development of sulcal span, thickness, curvature, and microstructure

Year: 2026

Type: article

Abstract: Cortical folding begins in utero as sulci emerge and continues postnatally as sulci deepen. However, the timeline and mechanisms underlying postnatal sulcal development remain unknown. Using structural and quantitative magnetic resonance imaging in infants from birth to one year of age, we longitudinally measured macroanatomical and microstructural development in major sulci that emerge in utero between the 16th and 31st gestational weeks. We find that sulci that emerge earlier in utero are deeper at birth and deepen at a slower rate postnatally than later emerging sulci. Sulci also become wider, thicker, and microstructurally denser, while their curvature decreases. Notably, mean sulcal depth is predicted by a weighted sum of sulcal span, thickness, curvature, and tissue microstructure, with differential weights across sulci. Analysis of local depth along the sulcus also reveals that deeper portions of sulci (fundi) have higher curvature and higher microstructural density than the surrounding sulcal walls. These data reveal that postnatal sulcal deepening is nonuniform and depends on the time of emergence in utero, tissue microstructure, and multiple macroanatomical factors. Together, these findings have important ramifications for theories of cortical folding and elucidating neurodevelopmental disorders and delays.

Source: Communications Biology

DOI: 10.1038/s42003-026-09536-8