Year: 2026
Type: article
Abstract: Objective: To explore the clinical features and treatment approaches for leukoencephalopathy with calcifications and cysts (LCC). Methods: We retrospectively analyzed a 22-year-old male patient with genetically confirmed LCC admitted to Qingdao University Affiliated Hospital in April 2019. The patient's clinical presentation, imaging characteristics, treatment course, and outcomes were summarized alongside a comprehensive literature review. Results: The patient underwent resection of bilateral frontal lobe cysts followed later by resection of a parietal lobe cyst. Postoperative pathology confirmed LCC with calcification and cystic changes. No severe postoperative complications occurred. Follow-up imaging demonstrated gradual cyst regression and symptom resolution. Genetic testing identified heterozygous SNORD118 variants (n.3C>T and n.74G>A). Conclusion: Surgical resection is an effective treatment for LCC cysts causing significant mass effect or neurological deficits, requiring regular follow-up. For smaller, asymptomatic cysts without mass effect, treatment with VEGF inhibitors (e.g., bevacizumab) may be beneficial. Management should be individualized.
Source: Frontiers in Neuroscience
Authors: Chao Guan, Huanting Li, Zechen Wang, Jie Wu, Yunqing Chen, Yugong Feng, Zhenwen Cui, Chen Shen, Pin Guo
Institutions: Qingdao University, Affiliated Hospital of Qingdao University
Language: English
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,801
OpenAlex ID: W7124444356