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Activation of SNr GABA neurons drives liver-brain-eye axis dysfunction in hepatic encephalopathy

Year: 2026

Type: article

Abstract: ) projections to the superior colliculus (SC) under AHE conditions. Chemogenetic inhibition of this pathway restored retinal function, normalized visual signal transmission, and reduced retinal γ-aminobutyric acid (GABA) release. These findings identify SNr-SC signaling as a key neural mechanism driving liver-brain-eye axis dysfunction in HE.

Source: iScience

DOI: 10.1016/j.isci.2026.114720

Authors: Kenan Li, Zhenhua Wang, Shaoheng Li, Feifei Wu, Yunhu Bai, Shujiao Li, Changlei Zhu, Ziwei Ni, Shuai Zhang, Yousheng Wu, Fei Tian, Nannan Liu, Tao Chen, Cailian Ruan, Zuoming Zhang, Yanling Yang, Yayun Wang

Institutions: Air Force Medical University, Xijing Hospital, Yan'an University

Language: English

Topic: Neuroscience and Neuropharmacology Research

Subfield: Cellular and Molecular Neuroscience

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,240

Funders: National Natural Science Foundation of China, Fourth Military Medical University, Natural Science Basic Research Program of Shaanxi Province

Awards: G1764478550, G234007633, G647152224, G7076368988, G7917683784

OpenAlex ID: W7124445218

FWCI:

Cites: 84

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