Work

Simultaneous inhibition of PARP/AKT to intercept nascent BRCA1/2mut breast tumors

Year: 2026

Type: article

Abstract: mouse model to investigate whether a pulse of PARP inhibitor (PARPi) ± an AKT inhibitor (AKTi) can prevent Brca1-related breast cancer. PARPi alone did not intercept or prevent tumor development. PARPi+AKTi intercepted tumors but did not prevent new tumors. These data confirm the efficacy of a PARPi and an inhibitor of PI3K signaling in treating BRCA1/2-related tumors, but this combination is not sufficient to prevent carcinogenesis.

Source: npj Breast Cancer

DOI: 10.1038/s41523-026-00892-6