Mixed evidence for stress effects on cortisol-testosterone coupling in Syrian refugee and Jordanian non-refugee adolescents
Year: 2026
Type: article
Study design: Observational Study
Abstract: INTRODUCTION: Pubertal development is governed by the HPA and HPG axes. Co-upregulation of the HPA/HPG during adolescence is hypothesized to produce positive cortisol-testosterone coupling to promote developmental demands of puberty, then attenuate post-puberty. However, effects of trauma and poverty-related stress on hormonal coupling are less substantiated. METHODS: We analyzed cross-sectional biological, sociodemographic, and displacement/poverty-related stress data from Syrian refugee and Jordanian non-refugee adolescents living in Northern Jordan (n = 768). We quantified free cortisol and free testosterone from dried bloodspots using mass spectrometry. We used Bayesian hierarchical models to assess the hypothesis that cortisol and testosterone are positively coupled during puberty but de-couple at later stages, and that patterns of hormonal coupling and de-coupling would vary by refugee status and indicators of early life stressors. RESULTS: We report some evidence for the hypothesis that cortisol and testosterone are coupled during pubertal ages 10-19. Positive hormonal coupling was most consistent among Syrian females with relatively higher lifetime trauma, distress/insecurity, household wealth, and mental health and resilience scores and Jordanian males, counterintuitively, with lower lifetime trauma, household wealth, mental health, and resilience scores. CONCLUSIONS: Our study contributes to understanding HPA and HPG patterning and integration across a wide range of adolescent ages among adolescents affected by conflict and poverty related stressors. Our findings offer limited support for the underlying hormonal coupling hypothesis, underscoring how growing bodies may be sensitive to environmental conditions at the extremes and that life history patterning varies with socioecological conditions.
Source: Psychoneuroendocrinology
Language: English
Subfield: Behavioral Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $3,830
Funders: National Science Foundation, Wenner-Gren Foundation, Yale University, University of Washington, National Institutes of Health, Center for Studies in Demography and Ecology, University of Washington, National Institute of Child Health and Human Development, Division of Behavioral and Cognitive Sciences, Eunice Kennedy Shriver National Institute of Child Health and Human Development
OpenAlex ID: W7124456513