Work

Hexokinase detachment from mitochondria drives the Warburg effect to support compartmentalized ATP production

Year: 2026

Type: article

Source: Nature Metabolism

DOI: 10.1038/s42255-025-01428-1

Authors: Kimberly S. Huggler, Kyle M. Flickinger, Matthew H. Forsberg, Carlos A. Mellado Fritz, Gavin R. Chang, Meghan F. McGuire, Christian M. Capitini, Jason R. Cantor

Institutions: University of Wisconsin–Madison, Morgridge Institute for Research, University of Wisconsin Carbone Cancer Center

Language: English

Topic: Cancer, Hypoxia, and Metabolism

Subfield: Cancer Research

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: American Cancer Society, University of Wisconsin-Madison, University of Wisconsin Carbone Cancer Center, Midwest Athletes Against Childhood Cancer, National Institutes of Health, National Human Genome Research Institute, National Cancer Institute

Awards: G4004214011, G5813506420, G6238290905, G9000320046, UW Comprehensive Cancer Center Support, Institutional Training in the Genomic Sciences

OpenAlex ID: W7124461461

FWCI: 22.27

Cites: 129

Cited by: 9

Related to: 10