Rationale and design of the Pre-MYO project: a precision-medicine platform for myocarditis diagnosis and management
Year: 2026
Type: article
Study design: Study Protocol
Abstract: INTRODUCTION: Myocarditis is an inflammatory disease characterized by a wide spectrum of clinical presentations, which complicates its diagnosis and management. The Precision Biomarkers for Diagnosis and Management of Myocardial Inflammatory Diseases (Pre-MYO) project aims to address three major gaps: (i) the limited knowledge regarding the epidemiology, clinical management and prognosis; (ii) the absence of specific and widely accessible biomarkers able to provide an early diagnosis (precision medicine); (iii) the lack of biomarkers of susceptibility to myocarditis, including risk of recurrence and disease severity (personalized medicine). STUDY DESIGN: The Pre-MYO is a prospective, observational and multicentre nationwide project designed to enrol 3000 patients with suspected myocarditis or inflammatory cardiomyopathy based on clinical findings. The registry includes extensive clinical characterization and long-term follow-up, including biobanks of blood samples, DNA, and cardiac magnetic resonance imaging (CMR). The platform will enable the investigation and validation of novel diagnostic and prognostic biomarkers, including the candidate hsa-RNA-Chr8:96, and the development of clinical trials. Predisposition studies will be conducted to investigate environmental and immune factors, genetic mutations, and acquired variants-including methylation analyses-that contribute to individual predisposition and risk. DISCUSSION: The Pre-MYO project will establish a collaborative research framework aimed at improving the understanding and clinical management of myocarditis by integrating precision and personalized medicine approaches.
Source: ESC Heart Failure
Authors: Domingo A Pascual-Figal, Azahara M García-Serna, Angel Esteban-Gil, José J Fuster, Pilar Martín, Fátima Sánchez-Cabo, Aitor Uribarri, Angel Manuel Iniesta-Manjavacas, Jose M Larrañaga-Moreira, Silvia Lopez-Fernandez, Pablo Pastor-Pueyo, Carles Diez-Lopez, José María Viéitez Flórez, Héctor Bueno, Marcelo Sanmartin-Fernandez, Juan Fernández-Martínez, Belén Álvarez Álvarez, Antonia Tercero Martinez, Fernando Domínguez
Institutions: Spanish National Centre for Cardiovascular Research, Centro de Investigación en Red en Enfermedades Cardiovasculares, Centro de Investigación Biomédica en Red, Instituto Murciano de Investigación Biosanitaria, Hospital Universitario Virgen de la Arrixaca, Universidad de Murcia, Vall d'Hebron Hospital Universitari, Hospital Universitario La Paz, Universidade da Coruña, Complexo Hospitalario Universitario A Coruña, Instituto de Investigación Biomédica de A Coruña, Instituto de Investigación Biosanitaria de Granada, Hospital Universitario Virgen de las Nieves, Hospital Universitari Arnau de Vilanova, Instituto de Investigación Biomédica de Lleida, Bellvitge University Hospital, Institut d'Investigació Biomédica de Bellvitge, Hospital Universitario Lucus Augusti, Hospital Universitario 12 De Octubre, Hospital Universitario Ramón y Cajal, Hospital de Sant Pau, Complejo Hospitalario Universitario de Santiago, Complejo Hospitalario Universitario de Albacete, Hospital Universitario Puerta de Hierro Majadahonda
Language: English
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $4,850
Awards: G1602493886, G2152959462, G2262748287, G288011245, BIOMARCADORES DE PRECISION PARA LA MEJORA DEL DIAGNOSTICO Y TRATAMIENTO DE LA ENFERMEDAD INFLAMATORIA DEL MIOCARDIO (PreMYO), G3480869486, G3681454997, G4042783231, G425668148, G5635532810, G7084143925, G7863371703, G8497050386, G8667377315, G926782147
OpenAlex ID: W7124595573