Year: 2026
Type: article
Study design: Case Report
Abstract: Background: Diabetic striatopathy (DS) is a rare neurological complication of diabetes mellitus, characterized by acute choreiform or ballistic movements and hyperintense basal ganglia lesions on T1-weighted MRI. While non-ketotic hyperglycemia is commonly implicated, DS can also occur in ketotic states. Case presentation: We report two elderly patients with long-standing, poorly controlled diabetes. Case 1, an 80-year-old male, presented with bilateral lower limb choreiform movements and delirium. Case 2, a 92-year-old female, developed right-sided hemichorea after discontinuing hypoglycemic therapy. Both patients had hyperglycemia with ketosis and characteristic basal ganglia T1 hyperintensity. Intensive glycemic control and symptomatic therapy led to complete resolution of involuntary movements in both cases. Conclusion: These cases highlight the heterogeneous clinical presentations of DS in advanced-aged patients and emphasize the importance of early recognition and prompt metabolic correction to achieve favorable neurological outcomes.
Source: Frontiers in Endocrinology
Authors: Yikai Liu, Wentan Huang, Zewei Mo, Weiping Wei
Institutions: Hainan General Hospital, Hainan Medical University
Language: English
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,801
OpenAlex ID: W7124746489