Year: 2026
Type: article
Abstract: Malaria control in Ghana and sub-Saharan Africa is threatened by widespread insecticide resistance in Anopheles gambiae s.l., undermining the effectiveness of long-lasting insecticidal nets and indoor residual spraying. A longitudinal survey was conducted between 2023 and 2025 across 20 urban and suburban sites spanning the coastal savannah, forest, and Sahel savannah zones. Of the 1,008 An. gambiae s.l. sampled, An. coluzzii was the dominant species (65.1%), followed by An. gambiae s.s. (18.9%) and An. arabiensis (10.9%). WHO bioassays revealed high pyrethroid resistance (mortality rate = 20–45%). Full susceptibility to pirimiphos-methyl (mortality rate = 99–100%) and chlorfenapyr was observed at most sites, though resistance to clothianidin was observed in Obuasi, Tema, and Abossey Okai. Intensity assays confirmed strong pyrethroid resistance even at 10× diagnostic concentrations. Genotyping showed near-fixation of the kdrL995F allele and the presence of additional resistance markers, including N1570Y, V402L, I1527T, and Ace-1R G280S.
Source: Gigabyte
Authors: Christopher Mfum Owusu-Asenso, Anisa Abdulai, Isaac Kwame Sraku, Yasmeen Amandi Acquah, Stephina Adjoa Yanney, Miriam DedeAma Dortey, Yaw Akuamoah-Boateng, Abdul Rahim Mohammed Sabtiu, Judith Dzifa Azumah, Abena Ahema Ebuako, Nutifafa Efui Abusa, Nana Kwame Baako, Christabel Asabea Koranteng, Ruth Owusu Kwarteng, Grace Arhin Danquah, Godfred Amoateng, Bright Churchill Obeng, Akua Obeng Forson, Cornelia Appiah-Kwarteng, Simon Kwaku Attah, Yaw Asare Afrane
Institution: University of Ghana
Language: English
Topic: Malaria Research and Control
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $350
OpenAlex ID: W7124758585