Work

Integration of Proximal Alkoxide and Lewis Acidic Cations To Boost Nickel-Catalyzed Borylation

Year: 2026

Type: article

Abstract: Nickel catalysis offers a sustainable alternative to palladium catalysis for cross-coupling reactions, yet ligands tailored for nickel catalysis are lacking. We introduce new phosphine ligands designed to facilitate the incorporation of Lewis acidic cations. The combination of a phosphinoalcohol ligand with either ( n -Bu) 2 Mg or KHMDS, as a source of Mg 2+ or K + cations respectively, proved to be optimal for the borylation of aryl chlorides. Studies verified that incorporation of Lewis acidic cations in the proximity of the Ni center enhances reactivity.

Source: Organic Letters

DOI: 10.1021/acs.orglett.5c05326

Authors: Benjamin S. Grills, Jennifer A. Garden, Benjamin N. Bhawal

Institution: University of Edinburgh

Language: English

Topic: Catalytic Cross-Coupling Reactions

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

Funders: UK Research and Innovation, Royal Society, University of Edinburgh, Engineering and Physical Sciences Research Council

Awards: G6786492897, G7860425838