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An aggressive and recurrent pediatric ganglioglioma with unusual genotype: A rare case report

Year: 2026

Type: article

Abstract: ABSTRACT: Ganglioglioma is a glioneuronal tumor comprised of a combination of neoplastic ganglion and glial cells and associated with mutations in the MAPK signaling pathway. It is considered a central nervous system (CNS) World Health Organisation grade 1 tumor and is usually seen in a younger age group, particularly in the first two decades of life. The most common location is the temporal lobe, although they can occur anywhere in the central nervous system. They usually have an excellent prognosis, but around 5% of gangliogliomas are associated with aggressive behavior. Recurrence or malignant transformation in gangliogliomas is rare. We report an unusual case of recurrent aggressive ganglioglioma in a 12-year-old child with unexpected novel genotypic expression along with a brief review of literature.

Source: Indian Journal of Pathology and Microbiology

DOI: 10.4103/ijpm.ijpm_742_24

Authors: Mangesh Londhe, Ruchika Chamaria, Sushama Gurwale, Charusheela Gore, Jacob Jeeson

Institutions: Dr. D. Y. Patil Medical College, Hospital and Research Centre, Dr. D.Y. Patil Vidyapeeth, Pune

Language: English

Topic: Glioma Diagnosis and Treatment

Subfield: Genetics

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $200