Work

KNSTRN knockdown impairs autophagy flux to inhibit bladder cancer progression

Year: 2026

Type: article

Abstract: experiments. Collectively, we demonstrate that KNSTRN knockdown induces intracellular ROS accumulation and lysosomal dysfunction, thereby disrupting autophagic flux and inhibiting BLCA progression.

Source: iScience

DOI: 10.1016/j.isci.2026.114734

Authors: Xianbin Huang, Yanqiu Meng, Jielong Song, Yizi Zhu, Jian Li, Yan Xi, Xiaodong Peng, Yaoyi Xiong

Institutions: Nanchang University, First Affiliated Hospital of Jiangxi Medical College, First Affiliated Hospital of Nanchang University, Jiangxi University of Traditional Chinese Medicine, Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine

Language: English

Topic: Autophagy in Disease and Therapy

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,240

Funders: National Natural Science Foundation of China, Natural Science Foundation of Jiangxi Province, Nanchang University, Wu Jieping Medical Foundation

Awards: G2310145442, G2544125406, G2840753919, G4796776401, G4886359511

OpenAlex ID: W7124856229

FWCI:

Cites: 37

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