A comparative analysis of CD70-directed CAR-T cells for glioblastoma treatment demonstrates a superior efficacy of the ligand-based construct
Year: 2026
Type: article
Abstract: and in immunocompetent GB mouse models, further underscoring the therapeutic promise of CD27 integration into the CAR design. Collectively, our comparative analysis highlights the superior efficacy of the ligand-based construct, supporting its incorporation into a clinical trial targeting CD70 in recurrent GB.
Source: Molecular Therapy Oncology
Authors: Alexandros Kourtesakis, Hiu Nam Hannah Chow, Eileen Bailey, Sandra Horschitz, Ammar Jabali, Rainer Will, Christoph Schifflers, Abigail K. Suwala, Hannah Rohdjess, Melissa Hahn, Yu-Chan Chih, Ling Hai, Denise Reibold, Sonja Pusch, Manuel Fischer, Ralph Sinn, Dennis Alexander Agardy, Dirk Carsten Frieder Hoffmann, Michael O. Breckwoldt, Robin Wagener, Leon Kaulen, Philipp Koch, Andreas von Deimling, Lukas Bunse, Michael Platten, Felix Sahm, Carsten Müller-Tidow, Michael Schmitt, Wolfgang Wick, Tim Sauer, Tobias Kessler
Language: English
Topic: CAR-T cell therapy research
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,900
Awards: G1589556947, G6282240877
OpenAlex ID: W7124862221