Work

Missing tissue, missing data: Resolving brain volume loss caused by anti-amyloid therapies

Year: 2026

Type: article

Abstract: Anti-amyloid drugs modestly slow Alzheimer's disease progression, albeit with uncertainty of sustained benefit, particularly as they cause paradoxical acceleration of brain volume changes. Here, we examine explanations for these volume changes and argue for transparent release of clinical trial data.

Source: PLoS Medicine

DOI: 10.1371/journal.pmed.1004880

Authors: Francesca Alves, Scott Ayton

Institutions: The University of Melbourne, Florey Institute of Neuroscience and Mental Health

Language: English

Topic: Alzheimer's disease research and treatments

Subfield: Physiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $6,460