Work

Aurkb deficiency disrupts microglial development, homeostasis and hinders remyelination following cuprizone-induced demyelination

Year: 2026

Type: article

Abstract: deletion inhibited microglial clearance of myelin debris, independent of reduced microglia numbers. This defect was associated with diminished autophagy. Together, these findings establish Aurkb as a key regulator of microglial development, homeostasis, and responses to remyelination.

Source: iScience

DOI: 10.1016/j.isci.2026.114718

Authors: Weixing Yan, Dong Xiang, Li Du, Di Zhu, Qi Jia, Yuting Liu, Siyu Wang, Li Liu, Haihao Guan, Yelin Zhao, Guan Jiang, Sijia Gao, Hui Wang

Institutions: Xuzhou Medical College, Affiliated Hospital of Xuzhou Medical College, Karolinska Institutet, Maternal and Child Health Hospital of Xuzhou

Language: English

Topic: Neuroinflammation and Neurodegeneration Mechanisms

Subfield: Neurology

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,240

Funders: Jiangsu Commission of Health, Jiangsu Pharmaceutical Association, National Natural Science Foundation of China, Natural Science Foundation of Jiangsu Province, Jiangsu Provincial Commission of Health and Family Planning, Graduate Research and Innovation Projects of Jiangsu Province

Awards: G1083593070, G2557337974, G2779560241, G3482635757, G4755639273, G7005407528, G8551771191

OpenAlex ID: W7124871375

FWCI: 2.411

Cites: 59

Cited by: 1

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