Work

Disruption of chrna5 blunts aversion and adaptive transcriptomic responses to nicotine and alcohol

Year: 2026

Type: article

Abstract: mutants also exhibited drug-independent changes in appetite and circadian rhythms. We expect these results to give new insights into genetic predisposition that modulates vulnerability to nicotine and alcohol abuse.

Source: iScience

DOI: 10.1016/j.isci.2026.114735

Authors: Tanisha Goel, Joshua Raine, Caroline Kibat, Jeff Winxin Collado, Tirtha Das Banerjee, Ajay S. Mathuru

Institutions: National University of Singapore, Yale-NUS College, Agency for Science, Technology and Research, Institute of Molecular and Cell Biology

Language: English

Topic: Nicotinic Acetylcholine Receptors Study

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,240

Funders: Yale-NUS College, National University of Singapore, Ministry of Education - Singapore

Awards: G1814287271, G301835167, G3664112419, G428996526, G575475967, G710021682

OpenAlex ID: W7124889935

FWCI: 1.857

Cites: 113

Cited by: 1

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