Accelerating AAV process development with high-throughput strategies
Year: 2026
Type: article
Abstract: Accelerating process development is essential for advancing viral vector manufacturing and enabling broader access to gene therapies. Advanced approaches, such as high-throughput process and analytical development (HTPAD), can provide a powerful framework to achieve this by combining automated experimentation with integrated analytics. Through parallelized chromatography screening and data-driven optimization, HTPAD compresses downstream development timelines, enhances scalability, and reduces costs. This article showcases case studies demonstrating its effectiveness in refining viral vector purification strategies, improving process robustness, and offering adaptable solutions applicable across multiple AAV serotypes.
Source: Cell and Gene Therapy Insights
Authors: Kevin Vera, Praveen Kusumanchi, Dan Matuszek, Junyan Zhang, Alejandro Becerra, Pouria Motevalian
Institution: Thermo Fisher Scientific (United States)
Language: English
Subfield: Genetics
Domain: Life Sciences
Open Access status: hybrid
OpenAlex ID: W7124891817
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