Work

Neurogenic pulmonary edema as a manifestation of multiple sclerosis relapses

Year: 2026

Type: article

Abstract: Neurogenic pulmonary edema (NPE) is a well-recognized manifestation of central nervous system insults (Theodore J, 1976). Both NPE and left ventricular failure can be seen in relapses of relapsing remitting multiple sclerosis (RRMS) (Melin J, 1996). This article presents two case reports demonstrating NPE presentation in the absence of left ventricular failure in addition to a review of the existing literature. The presented cases as well as previously published cases suggest NPE to be a rare but potentially fatal complication of MS relapse, especially in patients with medullary demyelination. This article seeks to encourage clinicians to maintain a high index of suspicion of NPE in MS patients presenting with unexplained cardiopulmonary symptoms and emphasizes early detection of brainstem lesions and continuous monitoring of cardiopulmonary function to support improved patient outcomes.

Source: Neuroimmunology Reports

DOI: 10.1016/j.nerep.2026.100275

Authors: Tayyebeh Saberbaghi, Niloofar Mortezaei, Elaheh Shahmiri, Reza Vosoughi

Institutions: York University, St. Michael's Hospital, University of Toronto

Language: English

Topic: Multiple Sclerosis Research Studies

Subfield: Pathology and Forensic Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,120