Work

Human cytomegalovirus infection and cognitive decline: insights from population and experimental studies

Year: 2026

Type: article

Abstract: , a ubiquitous DNA betaherpesvirus, is capable of persistent infection and immunomodulation, particularly in immunocompromised and elderly hosts. Emerging evidence links HCMV to neurodegenerative diseases through its multifaceted immunomodulatory effects. This review summarizes key viral architectures and mechanisms, epidemiological trends, and experimental data supporting HCMV's role in cognitive decline. We advocate for targeted antiviral strategies and vaccine development to clarify its contribution to neurodegeneration.

Source: Frontiers in Aging Neuroscience

DOI: 10.3389/fnagi.2025.1757461

Authors: Koon Chu Yaiw, Isidre A. Ferrer, Cecilia Söderberg-Nauclér, Dorota Religa

Institutions: Karolinska Institutet, Universitat de Barcelona, Karolinska University Hospital, University of Turku

Language: English

Topic: Cytomegalovirus and herpesvirus research

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,801